In a breakthrough study, researchers have revealed that prostate cancer is of five different types and each of these has a specific genetic fingerprint.
Scientists are hopeful that this finding will enable doctors to treat prostate cancer differently in future – targeting each type based on severity rather than opting for a common treatment for all.
Published in EBioMedicine and carried out by researchers at Cancer Research UK Cambridge Institute and Addenbrooke’s Hospital, the study involve study of samples of healthy and cancerous prostate tissue from more than 250 men. Researches looked for abnormal chromosomes and measured the activity of 100 different genes linked to the disease to conclude that there are five distinct types of the cancer each with a characteristic genetic fingerprint.
Researchers say that their analysis is better at predicting which cancers were likely to be the most aggressive than the tests currently used by doctors – including the PSA test and Gleason score; however, the findings needs to be confirmed in clinical trials with larger groups of men to establish their validity and usability.
Study author Dr Alastair Lamb, from the Cancer Research UK Cambridge Institute, said: “Our exciting results show that prostate cancer can be classified into five genetically-different types. These findings could help doctors decide on the best course of treatment for each individual patient, based on the characteristics of their tumour.
“The next step is to confirm these results in bigger studies and drill down into the molecular ‘nuts and bolts’ of each specific prostate cancer type. By carrying out more research into how the different diseases behave we might be able to develop more effective ways to treat prostate cancer patients in the future, saving more lives.”
Prostate cancer is the most common cancer in men in the UK, with around 41,700 cases diagnosed every year. There are around 10,800 deaths from the disease each year in the UK.
Professor Malcolm Mason, Cancer Research UK’s prostate cancer expert, said: “The challenge in treating prostate cancer is that it can either behave like a pussycat – growing slowly and unlikely to cause problems in a man’s lifetime – or a tiger – spreading aggressively and requiring urgent treatment. But at the moment we have no reliable way to distinguish them. This means that some men may get treatment they don’t need, causing unnecessary side effects, while others might benefit from more intensive treatment.
“This research could be game-changing if the results hold up in larger clinical trials and could give us better information to guide each man’s treatment – even helping us to choose between treatments for men with aggressive cancers. Ultimately this could mean more effective treatment for the men who need it, helping to save more lives and improve the quality of life for many thousands of men with prostate cancer.”
