Study cautions against combined use of antidepressants and painkillers
Though not conclusive, a new research has urged doctors to exercise due caution when prescribing antidepressants as well as painkillers to patients as a combined use of these drugs is said to increase risk of bleeding and could even lead to stroke.
In a study published in The BMJ, researchers based in Korea compared the risk of bleeding among patients treated with antidepressants with and without NSAIDs.
For the study, researchers used the Korean nationwide health insurance database and analysed data of over four million people who were prescribed antidepressants for the first time between 2009 and 2013.
NSAID prescriptions were obtained and hospital records were used to identify time to first admission with intracranial haemorrhage within 30 days of a new prescription. Factors that could affect the results, such as age, sex, and use of other medications, were taken into account.
Compared with use of antidepressants alone, the team found that combined use of antidepressants and NSAIDs was associated with a substantially increased bleeding risk.
They found no statistically meaningful differences in risk of bleeding between different types of antidepressant drugs, or with age. Being male was the most common factor for a higher risk of bleeding with combined use of antidepressants and NSAIDs.
“The addition of NSAIDs to antidepressant treatment increased the risk of intracranial haemorrhage within 30 days of the combination starting, especially in men,” conclude the authors. “This result adds to evidence confirming the increase of risk with combination use of antidepressants and NSAIDs.”
In an accompanying editorial, Dr Stewart Mercer at the University of Glasgow and colleagues at the University of Cambridge, say the results give some cause for concern.
They point out that both types of drug are widely used, and that co-morbidity of the conditions for which these drugs are used is very high – 65% of those with major depression also have chronic pain.
They urge family doctors to be extra vigilant in terms of prescribing behaviour and discussing the risks with patients, especially in deprived areas where “the combination of mental and physical problems (including chronic pain) is very common.” And they say further research is required to extend the findings over longer time periods and in differing populations.