Aspirin-Cancer trial, which began in UK, is the world’s largest

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With an aim to check whether aspirin can help stop the return of some cancers, a new clinical trial – largest of its kind – has been launched in the UK starting yesterday (October 22).

The trial – Add-Aspirin phase III trial – is running across 100 centers in the UK and will evaluate whether daily intake of aspirin can stop some forms of cancer including bowel, breast, oesophagus (food pipe), prostate and stomach cancer from returning. The study intends to recruit as many as 11,000 patients across UK who recently had, or are undergoing treatment for one of the above cancers.

In the clinical trial, which has been funded by Cancer Research UK and the National Institute for Health Research, researchers will be comparing two groups of people taking different doses of aspirin and a group taking placebo (dummy) tablets. While there have been prior studies that have proved that Aspirin is capable of preventing heart attacks and strokes, and a few small studies that have suggested that it could also prevent some types of cancer, this study is the largest of its kind that will enable researchers to more or less establish Aspirin’s capabilities against cancer.

Professor Ruth Langley, chief investigator from the MRC Clinical Trials Unit at UCL, said: “There’s been some interesting research suggesting that aspirin could delay or stop early stage cancers coming back, but there’s been no randomised trial to give clear proof. This trial aims to answer this question once and for all. If we find that aspirin does stop these cancers returning, it could change future treatment — providing a cheap and simple way to help stop cancer coming back and helping more people survive.

“But, unless you are on the trial, it’s important not to start taking aspirin until we have the full results as aspirin isn’t suitable for everyone, and it can have serious side effects. Please speak to your oncologist or research nurse if you would like to join the Add-Aspirin trial.”

Mother of two Alex King, 51, was diagnosed with breast cancer in December 2009. She said: “Having cancer was one of the toughest experiences of my life, but thankfully I was one of the lucky ones given the all-clear and I’ve been free of cancer for five years now. Any opportunity to reduce the chance of cancer coming back is incredibly important so patients can rest more easily, and it’s brilliant to see that Cancer Research UK is launching this new trial to see if aspirin can help do this.”

Professor Tom Walley, director of the NIHR Health Technology Assessment (HTA) programme, said: “We have funded the Add-Aspirin trial because it offers the exciting possibility of improved outcomes for patients, with a simple well tolerated intervention. The NIHR HTA programme prides itself on funding pragmatic clinical trials like this that can lead to tangible benefits to patients and could help fill important knowledge gaps for the NHS.”

Dr Fiona Reddington, Cancer Research UK’s head of population research, said: “Aspirin’s possible effects on cancer are fascinating and we hope this trial will give us a clear answer on whether or not the drug helps stop some cancers coming back.

“This trial is especially exciting as cancers that recur are often harder to treat so finding a cheap and effective way to prevent this is potentially game-changing for patients.”